Opening Asia for Russia

Chinese scientists have found a way to suppress Crohn's disease and ulcerative colitis

06.08.2022 ТАСС 47 просмотров

The development did not cause a negative immune response in mice and prevented inflammation in the intestines of sick rodents.


Chinese researchers have found that the symptoms of Crohn's disease and ulcerative colitis can be effectively suppressed with the help of small gold nanoparticles. The scientists' findings are published in the journal Fundamental Research.

Crohn's disease and ulcerative colitis are types of inflammatory bowel disease. During these processes, a person may have diarrhea, fever, abdominal pain, blood in the stool, ulcers in the mouth and other symptoms. Currently there is no cure for Crohn's disease, so the existing therapy is aimed at reducing the inflammatory process. In the treatment of ulcerative colitis, anti-inflammatory drugs are also used, but in some cases the patient may be operated on.

Researchers have developed an approach that suppresses inflammation and normalizes the work of the intestinal mucosa using a set of nanoparticles. These are spherical structures with a diameter of 25 nanometers, consisting of gold atoms.

It turned out that nanoparticles actively interact with hydrogen peroxide molecules, single oxygen atoms and other chemically aggressive molecules that accumulate in the intestines of patients. Researchers have suggested that they can be used to suppress symptoms.

To do this, scientists have developed a technique that allows the synthesis of nanoparticles at room temperature. The team tested the work of these structures on the cells of the intestine and the immune system. Experiments have shown that gold nanospheres suppressed inflammation, and also increased the activity of enzymes associated with the production of natural antioxidant molecules.

"Our nanoparticles suppressed inflammation in intestinal tissues for more than 24 hours. Their main advantage is that these nanostructures can be taken by mouth, which saves patients and doctors from having to carry out various invasive procedures," said a researcher at Sun Yat-sen University in Guangzhou (China)Wang Fei, whose words are quoted by the press service of the magazine.

Experiments on healthy mice and rodents suffering from ulcerative colitis showed that nanoparticles did not cause negative reactions from the immune system of mice, and also successfully suppressed inflammation in the intestines of sick rodents.

The researchers believe that these nanoparticles can become a safer and longer-acting alternative to anti-inflammatory drugs that are used now.
Subscribe:

News

Economy and business

Culture and recreation

Economy and business

14.08.2022 13

wef 2022

Society

14.08.2022 16

helicopter

Economy and business

13.08.2022 27

altai mishustin

Science and education

13.08.2022 21

India

Society

13.08.2022 27

uzbekistan constitution

Economy and business

13.08.2022 25

petrol

Economy and business

13.08.2022 35

Altai

Science and education

13.08.2022 25

satellite

Новости партнёров