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Ill residents of Wuhan “stocked up” with antibodies to SARS-CoV-2

10.04.2021 118 просмотров

Most of the recovered residents of Wuhan retained antibodies to the coronavirus. They remained in "working" condition even a year after the illness.

More than 70% of the residents of Wuhan and its suburbs examined by Chinese doctors, who had been ill with a coronavirus infection more than a year ago, have retained antibodies to SARS-CoV-2. This calls into question the theories that these antibodies disappear after a few months. The scientists published the results of the study on bioRxiv.

"This suggests that most donors retain long-term immunity to coronavirus and are protected from reinfection," the researchers wrote.

Discussions about whether the human body can develop long-term immunity to a new type of coronavirus have been ongoing since the beginning of the epidemic. Some studies say that SARS-CoV-2 prevents the formation of cells that can produce antibodies to the virus for a long time. According to  other studies, antibodies do not disappear in all patients, and in some cases, the number of cells that produce them increases.

Chinese doctors, led by Professor Xinxin Zhang of Shanghai Medical University, decided to test how long antibodies to SARS-CoV-2 persist. During their study, they observed the lives of more than 800 Wuhan residents who became infected with a new type of coronavirus in January-February last year.

Scientists periodically collected blood samples from the participants and tracked how the concentration of antibodies to coronavirus envelope proteins changed in it. It turned out that initially their number rapidly decreased, but by about the ninth month of observation, the concentration stabilized and after that remained at the same level.

Thanks to this, more than 70% of patients had enough antibodies so that the coronavirus could not gain a foothold in their body. At the same time, their blood serum can be used as a means to treat COVID-19 and protect the body of the most vulnerable categories of patients even a year after the donors had been ill with a coronavirus infection.

Interestingly, in the body of men and elderly residents of Wuhan, the concentration of antibodies was consistently higher than in other categories of the population. Scientists suggest that this is due to the fact that their disease is more severe. This factor, according to scientists, must be taken into account when collecting the plasma of recovered patients and using it for medical purposes.

In general, the results of the study, according to Zhang and his colleagues, say that vaccines can form long-term immunity to a new type of coronavirus and completely suppress its spread. In the near future, scientists plan to continue monitoring and monitor how the level of antibodies in the blood of those who have been ill for two or more years will change.

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